Gastric ontogeny: clinical implications

Gastric ontogeny: clinical implications.

The delivery of a preterm infant offers a unique opportunity to look directly upon the process of ontogeny, while at the same time organ immaturity is the basis of the clinical problems which challenge neonatal medicine. In recent years our knowledge of foregut ontogeny has increased, together with an increased body of clinical experience, yet the nutritional management of the preterm infant re...

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer.

Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastr...

Clinical implications of DLL4 expression in gastric cancer

BACKGROUND Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified. METHODS Gastric cancer cell lines and 180 gastric cancer patients were enrolled. DLL4 expression in gastric cancer cells and stroma was identified and evaluated immun...

Fibrogenesis: Mechanisms, Dynamics and Clinical Implications

Fibrosis is the pathological condition resulting in the growth of excess fibrous connective tissue in an organ or body system as a reparative or reactive process. In the field of clinical pathology, clinicians and medical scientists are endeavoring to translate experimental knowledge into effective, innovative treatments for a range of fibrotic conditions. The amelioration of whole organ functi...

Molecular Features and Their Clinical Implications on Gastric Adenocarcinoma